Description

Estriol-D1 is a deuterated analog of the endogenous estrogen hormone estriol, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of mass spectrometry-based quantification methods, particularly in regulated environments. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and bioanalytical sectors who require precise measurement of estriol levels in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary use as a stable isotope-labeled internal standard for the precise quantification of estriol in bioanalytical methods, minimizing matrix effects and improving data accuracy.
• Pharmaceutical R&D: Used in pharmacokinetic and metabolism studies to track the absorption, distribution, metabolism, and excretion (ADME) of estriol and related compounds.
• Clinical Diagnostics: Enables the development and validation of highly sensitive assays for measuring estriol in serum, plasma, or urine for diagnostic and monitoring purposes.
• Endocrinology Research: Facilitates fundamental research into estrogen signaling, hormone dynamics, and related physiological or pathological processes.
• Method Development & Validation: Serves as a critical reference material for developing, optimizing, and validating new analytical protocols in compliance with guidelines like FDA 21 CFR Part 11 or EMA.
• Quality Control in Manufacturing: Employed in the QC testing of pharmaceutical products containing estriol or its derivatives to ensure potency and purity.

Basic Information

Product Name	Estriol-D1
CAS No.	55727-98-5
Molecular Formula	C18H23D1O3
Molecular Weight	289.40 g/mol (approx.)
Synonyms	Estriol-16,16,17-d3 (common designation); 16,16,17-d3-Estriol; 1,3,5(10)-Estratrien-3,16α,17β-triol-16,16,17-d3; Deuterated Estriol; Estriol-d3 (often used interchangeably); E3-d3; Oestriol-D1
EINECS	Contact for details

Quality Control

Our Estriol-D1 is manufactured under strict quality management systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant in the container. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium incorporation)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.