Description

(4R,5R)-2,2,7,7-Tetramethyl-2,7-Disila-3,6-Dioxaoctane-4,5-Dicarboxylic Acid Dimethyl Ester is a high-purity, chiral organosilicon compound that serves as a critical building block in advanced organic synthesis. Its value lies in its unique structure, which provides a protected diol functionality and silicon-based stereocenters, enabling precise control in the construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials industries who require high-fidelity chiral intermediates for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the asymmetric synthesis of complex drug candidates, particularly in antiviral and anticancer research.
• Agrochemical Synthesis: Used in the production of enantiomerically pure pesticides and herbicides, where specific stereochemistry is crucial for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric catalysis.
• Advanced Material Monomer: Employed in the synthesis of specialty silicones and silicon-containing polymers with tailored properties for electronics or coatings.
• Academic & R&D: A valuable reagent for methodological development in organic and organometallic chemistry laboratories.
• Fine Chemical Production: Integral to the multi-step synthesis of high-value, optically active fine chemicals and flavors/fragrances.

Basic Information

Product Name	(4R,5R)-2,2,7,7-Tetramethyl-2,7-Disila-3,6-Dioxaoctane-4,5-Dicarboxylic Acid Dimethyl Ester
CAS No.	55659-11-5
Molecular Formula	C14H28O6Si2
Molecular Weight	348.53 g/mol
Synonyms	Dimethyl (4R,5R)-2,2,7,7-tetramethyl-2,7-disila-3,6-dioxaoctane-4,5-dicarboxylate; (4R,5R)-TADDOL dimethyl ether (silicon analog); (R,R)-2,2,7,7-Tetramethyl-2,7-disila-3,6-dioxaoctane-4,5-dicarboxylic acid dimethyl ester; (4R,5R)-Disila-TADDOL dimethyl ester; (R,R)-Disila-TADDOL-DME; Silicon-TADDOL derivative; Chiral disiloxane diester; 1,1,3,3-Tetramethyl-1,3-bis[(4R,5R)-4,5-bis(methoxycarbonyl)-1,3-dioxolan-2-yl]disiloxane (alternative structural name).
EINECS	Contact for details

Quality Control

Our (4R,5R)-2,2,7,7-Tetramethyl-2,7-Disila-3,6-Dioxaoctane-4,5-Dicarboxylic Acid Dimethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC and NMR, to confirm identity, enantiomeric excess, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.