Description

1-(Trimethylsilyl)-1H-Indole-3-Butanoic Acid Methyl Ester CAS NO 55590-99-3 is a specialized organosilicon derivative of indole-3-butyric acid, a key structural motif in bioactive chemistry. This compound serves as a versatile and protected synthetic intermediate, enabling the controlled introduction of the indole-3-butyric acid side chain in complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways where the indole scaffold is prevalent.
• Agrochemical Research: Used in the development of new plant growth regulators and fungicides, leveraging the biological activity of indole-3-butyric acid derivatives.
• Organic Synthesis Reagent: The trimethylsilyl (TMS) protecting group allows for selective reactions, making it a valuable tool in multi-step synthetic routes for complex natural products and fine chemicals.
• Material Science Precursor: Potential use in the synthesis of functionalized polymers or organic semiconductors that incorporate heterocyclic aromatic systems for electronic applications.
• Bioconjugation Chemistry: Can be employed to create labeled probes or linkers for biochemical research, attaching the indole moiety to other molecules of interest.

Basic Information

Product Name	1-(Trimethylsilyl)-1H-Indole-3-Butanoic Acid Methyl Ester
CAS No.	55590-99-3
Molecular Formula	C₁₆H₂₃NO₂Si
Molecular Weight	289.45 g/mol
Synonyms	Methyl 1-(Trimethylsilyl)-1H-indole-3-butanoate; 1H-Indole-3-butanoic acid, 1-(trimethylsilyl)-, methyl ester; Indole-3-butyric acid methyl ester, 1-TMS derivative; 1-TMS-indole-3-butyric acid methyl ester; Methyl 4-(1-(trimethylsilyl)-1H-indol-3-yl)butanoate; 3-Indolebutyric Acid Methyl Ester TMS Ether; 1-Trimethylsilylindole-3-butyric Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-1H-Indole-3-Butanoic Acid Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.