Description

Propionic-3,3,3-D3 Acid is a stable isotope-labeled analog of propionic acid, where three hydrogen atoms at the 3-position are replaced by deuterium. This precise labeling is critical for applications requiring high specificity and minimal background interference in analytical techniques. It is an essential reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require internal standards for mass spectrometry or probes for metabolic and kinetic studies.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in GC-MS and LC-MS analyses for accurate measurement of propionic acid and related compounds in complex matrices.
• Metabolic Pathway Tracing: Serves as a deuterium-labeled tracer in biomedical and biochemical research to study fatty acid metabolism and other metabolic processes.
• Pharmaceutical Research & Development: Employed in the synthesis of deuterated drug candidates for pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• NMR Spectroscopy: Acts as a useful probe in nuclear magnetic resonance spectroscopy due to the distinct properties of deuterium.
• Chemical Synthesis Intermediate: Used in specialized organic synthesis where the introduction of a deuterated propionyl group is required.
• Food & Environmental Analysis: Facilitates the accurate detection and quantification of propionates and related substances in food safety and environmental monitoring.

Basic Information

Product Name	Propionic-3,3,3-D3 Acid
CAS No.	55577-88-3
Molecular Formula	C3D3HO2 or CH3CH2COOD
Molecular Weight	77.09 g/mol
Synonyms	Propionic Acid-d3; [2H3]Propionic Acid; 3,3,3-Trideuteriopropanoic Acid; Deuterated Propionic Acid; Propanoic-3,3,3-d3 Acid; Propionic Acid (D3); CD3CD2COOH; Propionic Acid-d3 (side chain)
EINECS	Contact for details

Quality Control

Every batch of Propionic-3,3,3-D3 Acid is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with specifications typically meeting or exceeding the requirements for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profile is provided with each shipment to ensure traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) and strong acid/organic solvent nature, the container must be kept tightly sealed to prevent moisture absorption and degradation. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (Assay)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.