Description

2-O,5-O,6-o-Tris(Trimethylsilyl)-3-Deoxy-D-Ribo-Hexonic Acid γ-Lactone is a key protected sugar derivative and versatile synthetic intermediate in advanced organic chemistry. This compound is essential for researchers and manufacturers requiring precise control over stereochemistry and functional group manipulation in complex molecule synthesis. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of nucleoside analogs, antiviral agents, and other fine chemicals.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of modified nucleosides and carbohydrate-based active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Used in the development of prodrugs and novel antiviral compounds, particularly targeting RNA viruses.
• Glycochemistry & Glycobiology: Serves as a protected precursor for constructing complex oligosaccharides, glycoconjugates, and glycomimetics.
• Process Chemistry & Scale-up: Enables efficient, multi-step synthetic routes in kilo-lab and pilot plant production for fine chemicals.
• Academic & R&D Laboratories: A valuable tool for methodological development in synthetic organic chemistry and exploring new chemical spaces.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups provide selective protection for hydroxyl functions, facilitating complex multi-step syntheses.

Basic Information

Product Name	2-O,5-O,6-o-Tris(Trimethylsilyl)-3-Deoxy-D-Ribo-Hexonic Acid γ-Lactone
CAS No.	55570-78-0
Molecular Formula	C18H40O6Si3
Molecular Weight	448.78 g/mol
Synonyms	3-Deoxy-2,5,6-tri-O-trimethylsilyl-D-ribo-hexono-1,4-lactone; 2,5,6-Tri-O-trimethylsilyl-3-deoxy-D-ribo-hexonic acid γ-lactone; 3-Deoxy-2,5,6-tri-O-(trimethylsilyl)-D-ribo-hexono-1,4-lactone; Tris-O-trimethylsilyl-3-deoxy-D-ribo-hexonic acid lactone; Protected 3-deoxy-D-ribo-hexonic acid lactone; TMS-protected deoxy hexonic lactone
EINECS	Contact for details

Quality Control

Our 2-O,5-O,6-o-Tris(Trimethylsilyl)-3-Deoxy-D-Ribo-Hexonic Acid γ-Lactone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.