Description

2-O,4-O,5-o-Tris(Trimethylsilyl)-D-Glucuronic Acid 6,3-Lactone is a key protected intermediate in synthetic organic chemistry, specifically designed for the controlled introduction of glucuronic acid moieties. This compound is essential for researchers and manufacturers requiring precise stereochemistry and functional group protection in complex molecule synthesis. It is primarily utilized in the development of pharmaceuticals, advanced materials, and specialized biochemical probes where high-purity building blocks are critical.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of glycosylated drugs, prodrugs, and targeted therapeutic agents.
• Glycoconjugate Synthesis: Used in the preparation of complex oligosaccharides, glycopeptides, and other biologically active conjugates for research and development.
• Metabolite Standard: Serves as a protected standard or reference compound in analytical chemistry for studying drug metabolism and glucuronidation pathways.
• Chemical Derivatization: Employed in analytical techniques to enhance the detectability or volatility of glucuronic acid-containing compounds via silylation.
• Material Science Research: Acts as a precursor for synthesizing functionalized polymers or surfaces with specific carbohydrate-based properties.

Basic Information

Product Name	2-O,4-O,5-o-Tris(Trimethylsilyl)-D-Glucuronic Acid 6,3-Lactone
CAS No.	55556-97-3
Molecular Formula	C18H38O7Si3
Molecular Weight	462.75 g/mol
Synonyms	D-Glucuronic Acid, 2,4,5-tris-O-(trimethylsilyl)-, 6,3-lactone; 2,4,5-Tris-O-trimethylsilyl-D-glucurono-6,3-lactone; Tris(trimethylsilyl) D-glucuronic acid lactone; Protected D-Glucuronic Acid Lactone; TMS-Glucuronic Acid Lactone; Glucuronic Acid Tris(TMS) Lactone; 6,3-Lactone of 2,4,5-Tri-O-trimethylsilyl-D-glucuronic Acid
EINECS	Contact for details

Quality Control

Our production of 2-O,4-O,5-o-Tris(Trimethylsilyl)-D-Glucuronic Acid 6,3-Lactone adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and synthesis. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can compromise product integrity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.