Description

D-Ribose, 2,3,4-Tris-o-(Trimethylsilyl)-, 5-[Bis(Trimethylsilyl) Phosp Hate] is a highly specialized, protected ribose derivative used as a key synthetic intermediate in advanced organic chemistry. This compound matters for its role in facilitating complex nucleoside and nucleotide synthesis, where protecting groups are essential for selective reactivity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antiviral drugs, modified oligonucleotides, and novel carbohydrate-based therapeutics. Its precise structure enables controlled phosphorylation and glycosylation reactions critical for producing high-value bioactive molecules.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Oligonucleotide Synthesis: Used in the research and development of modified RNA/DNA strands for therapeutic and diagnostic applications.
• Carbohydrate Chemistry Research: Serves as a protected substrate for studying phosphorylation mechanisms and enzymatic transformations.
• Prodrug Development: Employed in creating prodrug forms of nucleotide-based active pharmaceutical ingredients (APIs) to improve bioavailability.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged nucleotides for metabolic pathway tracing and target identification studies.
• Academic & Industrial R&D: A valuable reagent for laboratories focusing on synthetic methodology development in medicinal chemistry.

Basic Information

Product Name	D-Ribose, 2,3,4-Tris-o-(Trimethylsilyl)-, 5-[Bis(Trimethylsilyl) Phosp Hate]
CAS No.	55520-86-0
Molecular Formula	C20H53NO7PSi5
Molecular Weight	635.18 g/mol
Synonyms	5-[Bis(trimethylsilyl)phosphato]-2,3,4-tris-O-(trimethylsilyl)-D-ribose; D-Ribose, 2,3,4-tris-O-(trimethylsilyl)-, 5-[bis(trimethylsilyl) phosphate]; 2,3,4-Tri-O-trimethylsilyl-D-ribofuranose 5-bis(trimethylsilyl) phosphate; Protected D-Ribose Phosphate; TMS-Ribose Phosphate Derivative; Silylated Ribose Phosphate Ester
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research. Each lot is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ³¹P) and HPLC to confirm structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical development projects upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. For long-term stability, consider storage in a desiccator or under a nitrogen blanket.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (³¹P NMR)	≥ 90%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.