Description

D-Mannose, 2,3,4,5-Tetrakis-o-(Trimethylsilyl)-, 6-[Bis(Trimethylsilyl ) Phosphate] is a highly functionalized, silyl-protected derivative of D-mannose, designed for advanced synthetic applications. This compound is a critical protected intermediate that enables precise and efficient glycosylation and phosphorylation reactions in complex organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the production of nucleoside analogs, carbohydrate-based drugs, and sophisticated molecular probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleoside and nucleotide analogs with antiviral or anticancer activity.
• Carbohydrate Chemistry: Protected precursor for the controlled synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Process Chemistry: High-purity intermediate used in the scale-up and manufacturing of active pharmaceutical ingredients (APIs) requiring specific glycosylation patterns.
• Biochemical Research: Tool compound for studying enzyme mechanisms, such as those of kinases and phosphorylases, in carbohydrate metabolism.
• Labeled Compound Synthesis: Starting material for introducing isotopic labels (e.g., 13C, 2H) into sugar moieties for metabolic tracing and imaging studies.
• Glycopolymer & Material Science: Monomer for creating novel bio-inspired polymers with tailored surface properties and biocompatibility.

Basic Information

Product Name	D-Mannose, 2,3,4,5-Tetrakis-o-(Trimethylsilyl)-, 6-[Bis(Trimethylsilyl ) Phosphate]
CAS No.	55520-82-6
Molecular Formula	C24H61O11PSi6
Molecular Weight	709.28 g/mol
Synonyms	D-Mannose 2,3,4,5-tetrakis-O-(trimethylsilyl) 6-[bis(trimethylsilyl) phosphate]; 6-O-[Bis(trimethylsilyl)phosphoryl]-1,2,3,4,5-penta-O-trimethylsilyl-D-mannopyranose; 1,2,3,4,5-Penta-O-trimethylsilyl-6-O-[bis(trimethylsilyl)phosphoryl]-D-mannopyranose; Penta-TMS Mannose-6-bis(TMS)phosphate; Protected Mannose-6-Phosphate Derivative; TMS-Mannose-6-phosphate (fully protected); Silylated Mannose Phosphate Ester
EINECS	Contact for details

Quality Control

Our D-Mannose, 2,3,4,5-Tetrakis-o-(Trimethylsilyl)-, 6-[Bis(Trimethylsilyl ) Phosphate] is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including NMR (1H, 13C, 31P), HPLC, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container to prevent decomposition. For long-term storage, consider storing under inert gas in a freezer (-20°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.