Description

n-Methoxyphosphorimidic Acid Bis(Trimethylsilyl)[(2R,3R)-4-Oxo-2,3-Bis(Trimethylsilyloxy)Butyl] Ester is a highly specialized, chiral organophosphorus reagent featuring multiple silyl-protecting groups. This compound is critical for synthetic chemists as it serves as a key intermediate in the stereoselective synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D laboratories and production facilities in the fine chemical, agrochemical, and advanced pharmaceutical sectors for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of chiral active pharmaceutical ingredients (APIs), especially for antiviral and anticancer drug candidates.
• Asymmetric Synthesis: Used as a chiral auxiliary or reagent in stereocontrolled carbon-carbon and carbon-heteroatom bond-forming reactions.
• Nucleoside & Nucleotide Chemistry: Key intermediate for the preparation of modified nucleosides and nucleotides used in medicinal chemistry and biochemical research.
• Protecting Group Strategy: The bis(trimethylsilyl) groups provide temporary protection for sensitive hydroxyl functionalities during complex synthetic sequences.
• Agrochemical Synthesis: Employed in the research and development of novel, chiral pesticides and herbicides requiring high stereochemical purity.
• Process Chemistry Development: Serves as a high-value intermediate for scaling up synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	n-Methoxyphosphorimidic Acid Bis(Trimethylsilyl)[(2R,3R)-4-Oxo-2,3-Bis(Trimethylsilyloxy)Butyl] Ester
CAS No.	55517-61-8
Molecular Formula	C20H48NO6PSi4
Molecular Weight	558.0 g/mol (approx.)
Synonyms	(2R,3R)-4-Oxo-2,3-bis[(trimethylsilyl)oxy]butyl N-methoxy-P,P-bis(trimethylsilyl)phosphinimidate; (2R,3R)-4-Oxo-2,3-bis(trimethylsiloxy)butyl N-methoxy-P,P-bis(trimethylsilyl)phosphinimidate; (2R,3R)-4-Oxo-2,3-bis-O-(trimethylsilyl)butyl N-methoxy-P,P-bis(trimethylsilyl)phosphinimidate; n-Methoxy-P,P-bis(trimethylsilyl)phosphinimidic Acid (2R,3R)-4-Oxo-2,3-bis(trimethylsiloxy)butyl Ester; CAS 55517-61-8; Phosphorimidic acid derivative, silylated
EINECS	Contact for details

Quality Control

Our production of this high-purity synthetic intermediate adheres to strict in-process controls to ensure batch-to-batch consistency and stereochemical integrity. Quality is verified through comprehensive analytical methods including Chiral HPLC, 1H/31P/13C NMR, and GC-MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, enantiomeric excess, and key physicochemical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach ambient temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.