Description

n-(Trimethylsilyl)-n-[4-(Trimethylsiloxy)Benzoyl]Glycine Trimethylsilyl Ester is a specialized organosilicon derivative of glycine, extensively used as a key synthetic intermediate and protecting group reagent. Its value lies in its ability to enhance solubility and stability in organic synthesis, particularly for sensitive or complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require high-purity intermediates for peptide mimetics, prodrug development, and silicon-based chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for prodrug strategies and peptide-based therapeutics.
• Peptide Mimetics & Modifications: Used to introduce trimethylsilyl protecting groups onto amino acids, facilitating complex peptide synthesis and creating silicon-containing peptide analogs.
• Advanced Organic Synthesis: Serves as a versatile reagent for introducing silyl groups, enabling solubility enhancement and protecting carboxyl and hydroxyl functionalities in multi-step syntheses.
• Prodrug Development: Employed in the design and synthesis of prodrug candidates to improve the pharmacokinetic properties of drug molecules.
• Material Science Research: Acts as a precursor or modifying agent in the development of specialty silicon-based polymers and hybrid organic-inorganic materials.
• Analytical Chemistry: Utilized as a derivatization agent for gas chromatography (GC) or mass spectrometry (MS) to improve the volatility and detection of carboxylic acids and related compounds.

Basic Information

Product Name	n-(Trimethylsilyl)-n-[4-(Trimethylsiloxy)Benzoyl]Glycine Trimethylsilyl Ester
CAS No.	55517-55-0
Molecular Formula	C18H33NO4Si3
Molecular Weight	423.71 g/mol
Synonyms	Glycine, N-(trimethylsilyl)-N-[4-(trimethylsiloxy)benzoyl]-, trimethylsilyl ester; N-(Trimethylsilyl)-N-[4-(trimethylsilyloxy)benzoyl]glycine trimethylsilyl ester; Tris(trimethylsilyl) Glycine Benzoyl Ester; TMS-Glycine-TMS Ester Benzoyl Derivative; 4-(Trimethylsiloxy)benzoic Acid Glycine Tris(trimethylsilyl) Ester; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)-n-[4-(Trimethylsiloxy)Benzoyl]Glycine Trimethylsilyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance as a synthetic intermediate. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.