Description

4-Pregnen-21-Ol-3,20-Dione-2,2,4,6,6,17Alpha,21,21-D8 is a high-purity, deuterium-labeled analog of corticosterone, a key intermediate steroid hormone. This compound is critical for research and development in analytical chemistry, serving as an essential internal standard for mass spectrometry to ensure accurate quantification and method validation. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on endocrinology, metabolism studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of endogenous corticosterone and related steroids in complex biological matrices like plasma, serum, and tissue homogenates.
• Biomarker Research: Used in studies investigating the hypothalamic-pituitary-adrenal (HPA) axis, stress response, and metabolic disorders.
• Pharmaceutical Development: Supports pharmacokinetic (PK) and pharmacodynamic (PD) studies for drug candidates targeting corticosteroid pathways.
• Clinical Diagnostics: Enables the development and validation of robust clinical assays for hormonal imbalance diagnostics.
• Quality Control Reference: Serves as a certified reference material (CRM) for ensuring the accuracy and reliability of analytical testing in GLP/GMP environments.

Basic Information

Product Name	4-Pregnen-21-Ol-3,20-Dione-2,2,4,6,6,17Alpha,21,21-D8
CAS No.	55487-63-3
Molecular Formula	C₂₁H₂₂D₈O₃
Molecular Weight	350.50 g/mol (approx.)
Synonyms	Corticosterone-d8; 11β,21-Dihydroxypregn-4-ene-3,20-dione-d8; 11β,21-Dihydroxyprogesterone-d8; [2,2,4,6,6,17α,21,21-²H₈]Corticosterone; Deuterated Corticosterone; 4-Pregnene-11β,21-diol-3,20-dione-d8
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically >98 atom % D), chemical purity (by HPLC), and confirming identity and purity. We support compliance with ISO 17034 and ISO/IEC 17025 requirements for reference material producers.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Under these conditions, the product is stable for at least 24 months from the date of receipt. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. This material is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.