Description

n-(Methyl-D3)-3-Phenylpropylamine is a deuterated analog of 3-phenylpropylamine, where three hydrogen atoms on the methyl group are replaced by deuterium. This compound is a crucial stable isotope-labeled building block, providing enhanced metabolic stability and traceability in research applications. It is primarily utilized by pharmaceutical R&D laboratories, analytical chemists, and manufacturers of reference standards for drug discovery, metabolic studies, and quantitative mass spectrometry.

Application

• Pharmaceutical Research & Development: As a deuterated intermediate or precursor in the synthesis of novel active pharmaceutical ingredients (APIs) for improved pharmacokinetic profiles.
• Metabolic Pathway Tracing: Serving as a stable isotope-labeled internal standard in mass spectrometry for accurate quantification and metabolic flux analysis in biological systems.
• Analytical Reference Standards: Used in the preparation of certified reference materials (CRMs) for method validation, quality control, and regulatory compliance in analytical laboratories.
• Deuterated Probe Synthesis: A key starting material for creating deuterium-labeled probes and ligands used in NMR spectroscopy and mechanistic studies.
• Isotope Effect Studies: Enabling investigation of kinetic isotope effects (KIEs) in organic and medicinal chemistry to elucidate reaction mechanisms.

Basic Information

Product Name	n-(Methyl-D3)-3-Phenylpropylamine
CAS No.	55469-88-0
Molecular Formula	C10H12D3N
Molecular Weight	152.25 g/mol
Synonyms	3-Phenylpropylamine-d3 (methyl-d3); N-(Trideuteriomethyl)-3-phenylpropan-1-amine; (3-Phenylpropyl)(methyl-d3)amine; 1-Amino-3-phenylpropane-d3 (methyl-d3); Benzenepropanamine, N-methyl-d3-; Deuterated N-Methyl-3-phenylpropylamine; N-Methyl-d3-3-phenyl-1-propanamine
EINECS	Contact for details

Quality Control

Our n-(Methyl-D3)-3-Phenylpropylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ²H, ¹³C) and HPLC/MS to confirm isotopic purity, chemical purity, and identity. Certificates of Analysis (COA) detailing batch-specific results for isotopic enrichment (typically >98 atom % D), chemical purity (typically >97%), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isotopic Purity (²H NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.