Description

n-[(R)-2-[3,4-Bis[(Trimethylsilyl)Oxy]Phenyl]-2-[(Trimethylsilyl)Oxy]Ethyl]-N,α,α,α-Tetramethylsilanamine is a sophisticated organosilicon compound, specifically a silylated derivative of a chiral amino alcohol. This high-purity intermediate is valued for its role in advanced organic synthesis, particularly in the production of complex pharmaceutical molecules where precise stereochemistry and functional group protection are critical. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in stereoselective reactions to introduce specific stereocenters with high enantiomeric purity.
• Functional Group Protection: The trimethylsilyl (TMS) groups serve as protective agents for hydroxyl and amine functionalities during multi-step synthetic sequences.
• Advanced Material Research: Used in the development of novel silicon-containing organic frameworks and specialty polymers.
• Process Chemistry Development: Serves as a reference standard or starting material for scaling up synthetic routes in pilot plants and commercial manufacturing.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, catalysis, and medicinal chemistry programs.

Basic Information

Item	Detail
Product Name	n-[(R)-2-[3,4-Bis[(Trimethylsilyl)Oxy]Phenyl]-2-[(Trimethylsilyl)Oxy]Ethyl]-N,α,α,α-Tetramethylsilanamine
CAS No.	55429-87-3
Molecular Formula	C22H45NO3Si4
Molecular Weight	503.96 g/mol
Synonyms	(R)-2-[3,4-Bis(trimethylsiloxy)phenyl]-2-(trimethylsiloxy)-N,N,N-trimethylethanaminium; N-[(1R)-2-[3,4-Bis(trimethylsilyloxy)phenyl]-2-(trimethylsilyloxy)ethyl]-N,N,N-trimethylsilanaminium; Tris(trimethylsilyl) ether derivative of (R)-norepinephrine; TMS-protected (R)-norepinephrine derivative; Silicon analog of a chiral amino alcohol; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Every batch of our n-[(R)-2-[3,4-Bis[(Trimethylsilyl)Oxy]Phenyl]-2-[(Trimethylsilyl)Oxy]Ethyl]-N,α,α,α-Tetramethylsilanamine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC/NMR), chiral purity, and impurity profiles are available for each lot. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.