Description

2-Cyanoacetamide, [Cyano-14C] is a carbon-14 labeled isotopologue of the versatile organic synthon 2-cyanoacetamide. This radiolabeled compound is essential for conducting precise metabolic and pharmacokinetic studies, enabling researchers to trace the fate of molecules within complex biological systems. It is a critical tool for scientists in pharmaceutical R&D, agrochemical development, and advanced organic synthesis who require high-specific-activity tracers for autoradiography, ADME (Absorption, Distribution, Metabolism, and Excretion) studies, and pathway elucidation.

Application

• Pharmaceutical Research & Development: As a radiolabeled precursor for synthesizing carbon-14 labeled drug candidates and metabolites for definitive ADME and mass balance studies.
• Agrochemical Metabolism Studies: Tracing the environmental fate, plant uptake, and metabolic pathways of pesticides and herbicides derived from cyanoacetamide chemistry.
• Biochemical Tracer Synthesis: Incorporation into labeled peptides, nucleotides, or other bioactive molecules to study protein interactions, enzyme mechanisms, and biochemical pathways.
• Organic Synthesis Intermediate: Serving as a labeled building block for the preparation of heterocyclic compounds, such as pyrimidines and purines, in research-scale synthesis.
• Metabolic Pathway Analysis: Use in autoradiography and LC-MS/MS studies to visualize and quantify the distribution and biotransformation of compounds in vitro and in vivo.

Basic Information

Product Name	2-Cyanoacetamide, [Cyano-14C]
CAS No.	55390-83-5
Molecular Formula	C3H414CN2O
Molecular Weight	~85.05 g/mol (varies with specific activity)
Synonyms	2-Cyanoacetamide-1-14C; [14C]Cyanoacetamide; Acetamide, 2-cyano-1-14C; 3-Oxo-3-14C-propanenitrile; Malonamide nitrile-14C; Carbon-14 Labeled Cyanoacetamide; 2-Cyanoacetamide-cyano-14C; NSC 8427 (labeled)
EINECS	Contact for details

Quality Control

Every batch of our carbon-14 labeled 2-Cyanoacetamide is manufactured and analyzed under strict quality systems to ensure radiochemical purity, chemical purity, and specific activity meet the exacting standards required for research. Comprehensive analysis includes HPLC with radiometric detection, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA), specifying batch-specific data on purity, activity, and solvent content, is provided with each shipment to support regulatory submissions and ensure experimental reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage at or below -20°C under inert atmosphere. All handling must be performed in accordance with local radiation safety regulations and guidelines for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	Customizable (mCi/mmol range)
Solvent Content (Residual Solvents)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.