Description

2-Bromo-5-Fluorobenzenethiol is a versatile organosulfur building block characterized by its reactive thiol (-SH) group and halogen substituents. This compound is essential for introducing specific sulfur-containing motifs into complex molecular architectures, enabling the synthesis of advanced materials and pharmaceuticals. It is primarily sought after by researchers and process chemists in the agrochemical, pharmaceutical, and material science industries for applications in cross-coupling reactions, ligand synthesis, and as a key intermediate in drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing aryl thioether or disulfide linkages.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromo and fluoro substituents modulate biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Ligand and Catalyst Development: Employed in the preparation of sulfur-containing ligands for transition metal catalysis, enhancing reaction selectivity and efficiency.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for constructing complex biaryl systems.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	2-Bromo-5-Fluorobenzenethiol
CAS No.	55389-14-5
Molecular Formula	C6H4BrFS
Molecular Weight	207.06 g/mol
Synonyms	2-Bromo-5-fluorobenzenethiol; 2-Bromo-5-fluorothiophenol; 5-Fluoro-2-bromobenzenethiol; 1-Bromo-4-fluoro-2-mercaptobenzene; Benzenethiol, 2-bromo-5-fluoro-; (2-Bromo-5-fluorophenyl)thiol; 2-Bromo-5-fluorophenyl mercaptan
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluorobenzenethiol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.