Description

(R)-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One CAS NO 55375-92-3 is a high-purity, chiral organic compound belonging to the tetrahydroisoquinoline class, characterized by its fused pyrazino ring system. This advanced pharmaceutical intermediate is valued for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including potential candidates for neurological and cardiovascular applications.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold or precursor in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Asymmetric Synthesis: Serves as a starting material or intermediate in enantioselective synthesis routes due to its defined (R)-configuration.
• Neurological Drug Development: Potential building block for compounds targeting central nervous system (CNS) disorders.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for exploratory chemical synthesis.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of complex drug candidates.

Basic Information

Product Name	(R)-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One
CAS No.	55375-92-3
Molecular Formula	C₁₃H₁₄N₂O
Molecular Weight	214.26 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydro-2-methyl-4-oxopyrazino[2,1-a]isoquinoline; (R)-2-Methyl-1,2,3,4-tetrahydro-4-oxopyrazino[2,1-a]isoquinoline; (R)-2-Methyl-1,2,3,4-tetrahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; (R)-2-Methyl-1,2,3,4-tetrahydro-pyrazino[2,1-a]isoquinolin-4-one; (R)-2-Methyl-1,2,3,4-tetrahydro-4H-pyrazino[2,1-a]isoquinoline-4-one; (R)-2-Methyl-1,2,3,4-tetrahydro-4-oxopyrazino[2,1-a]isoquinoline; (R)-2-Methyl-1,2,3,4-tetrahydro-4H-pyrazino[2,1-a]isoquinolinone
EINECS	Contact for details

Quality Control

Our production of (R)-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is fully characterized and undergoes rigorous analytical testing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.