Description

1-(4-Chlorobenzoyl)-2-Methyl-5-(Trimethylsilyl)Oxy-1H-Indole-3-Acetic Acid Methyl Ester is a high-purity, synthetically valuable indole derivative. This compound serves as a critical advanced pharmaceutical intermediate in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other indole-based therapeutic compounds.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Process Chemistry: Serves as a precursor in scalable API manufacturing processes, where its protected functional groups allow for selective downstream reactions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Custom Synthesis: Starting material for the preparation of more complex, tailored molecules for specialized clinical or research applications.

Basic Information

Product Name	1-(4-Chlorobenzoyl)-2-Methyl-5-(Trimethylsilyl)Oxy-1H-Indole-3-Acetic Acid Methyl Ester
CAS No.	55334-99-1
Molecular Formula	C22H24ClNO4Si
Molecular Weight	429.97 g/mol
Synonyms	5-[(Trimethylsilyl)oxy]-1-(4-chlorobenzoyl)-2-methyl-1H-indole-3-acetic acid methyl ester; Methyl 1-(4-chlorobenzoyl)-2-methyl-5-[(trimethylsilyl)oxy]-1H-indole-3-acetate; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-2-methyl-5-[(trimethylsilyl)oxy]-, methyl ester; TMS-protected Indole Acetate Ester; 55334-99-1
EINECS	Contact for details

Quality Control

Our production of 1-(4-Chlorobenzoyl)-2-Methyl-5-(Trimethylsilyl)Oxy-1H-Indole-3-Acetic Acid Methyl Ester adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS), to ensure it meets precise customer specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.