Description

Phosphoric Acid 2-[(E)-Ethoxyimino]-3-[(Trimethylsilyl)Oxy]Propylbis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphate derivative, designed for advanced synthetic applications where precise control over reactivity is paramount. This compound serves as a key synthetic intermediate and protecting group reagent, enabling complex chemical transformations in sensitive environments. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis laboratories for the development of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex drug candidates, particularly those containing phosphate or phosphonate functional groups.
• Nucleotide & Oligonucleotide Chemistry: Used in the protection and controlled phosphorylation steps during the synthesis of modified nucleotides and oligonucleotide analogs for therapeutic and diagnostic applications.
• Peptide Modification: Facilitates the site-specific introduction of phosphate or phosphonate moieties onto peptides and proteins for biochemical research and drug development.
• Catalyst & Ligand Synthesis: Serves as a precursor for synthesizing specialized organophosphorus ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel silicon-containing polymers and surface-modifying agents with tailored properties.
• Protecting Group Reagent: Provides a robust, silyl-based protecting strategy for phosphate groups, allowing selective deprotection under mild conditions in complex synthetic sequences.

Basic Information

Product Name	Phosphoric Acid 2-[(E)-Ethoxyimino]-3-[(Trimethylsilyl)Oxy]Propylbis(Trimethylsilyl) Ester
CAS No.	55334-93-5
Molecular Formula	C17H42NO5PSi3
Molecular Weight	467.83 g/mol
Synonyms	2-[(E)-Ethoxyimino]-3-[(trimethylsilyl)oxy]propyl bis(trimethylsilyl) phosphate; Phosphoric Acid, 2-[(E)-Ethoxyimino]-3-[(trimethylsilyl)oxy]propyl Ester, bis(trimethylsilyl) Ester; Tris(trimethylsilyl) 2-[(E)-ethoxyimino]-3-[(trimethylsilyl)oxy]propyl Phosphate; TMS-Protected Phosphoryl Oxime Ester; (E)-2-(Ethoxyimino)-3-((trimethylsilyl)oxy)propyl Bis(trimethylsilyl) Phosphate
EINECS	Contact for details

Quality Control

Every batch of our Phosphoric Acid 2-[(E)-Ethoxyimino]-3-[(Trimethylsilyl)Oxy]Propylbis(Trimethylsilyl) Ester is manufactured and tested under strict quality management protocols. We guarantee high chemical purity and lot-to-lot consistency, with comprehensive analytical characterization including NMR, HPLC, and GC-MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.