Description

(2R)-2,3-Bis[Bis(Trimethylsilyloxy)Phosphinyloxy]Propionic Acid Trimethylsilyl Ester CAS NO 55334-89-9 is a highly specialized organosilicon-protected phosphonic acid derivative, serving as a critical chiral building block and protecting group reagent in advanced organic synthesis. Its value lies in enabling precise synthetic pathways for complex molecules where control over stereochemistry and functional group manipulation is paramount. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the synthesis of nucleotide analogs, phospholipids, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of antiviral and anticancer nucleotide analogs.
• Phospholipid Synthesis: Used in the preparation of synthetic phospholipids and phosphonate-containing lipids for drug delivery systems and membrane research.
• Agrochemical Development: Acts as a building block for novel herbicides and plant growth regulators containing phosphonate moieties.
• Peptide & Protein Modification: Employed for the site-specific phosphorylation or phosphonylation of amino acids and peptides.
• Catalyst & Ligand Preparation: Serves as a precursor for chiral phosphonate-based ligands used in asymmetric catalysis.
• Material Science Research: Utilized in the synthesis of functionalized surfaces and polymers with specific phosphate-mimicking properties.
• Protecting Group Chemistry: The trimethylsilyl groups provide robust protection for phosphonic acid functionalities during multi-step syntheses.

Basic Information

Item	Detail
Product Name	(2R)-2,3-Bis[Bis(Trimethylsilyloxy)Phosphinyloxy]Propionic Acid Trimethylsilyl Ester
CAS No.	55334-89-9
Molecular Formula	C18H51O10P2Si5
Molecular Weight	~ 642.1 g/mol
Synonyms	(2R)-2,3-Bis[bis(trimethylsiloxy)phosphinyloxy]propionic acid trimethylsilyl ester; (R)-2,3-Bis(bis(trimethylsiloxy)phosphinyloxy)propionic acid TMS ester; Propanoic acid, 2,3-bis[bis(trimethylsiloxy)phosphinyl]-, 1-(trimethylsilyl) ester, (2R)-; TMS-protected (R)-glycerol phosphonate; Chiral glycerol-1,2-bisphosphonate TMS ester; CAS 55334-89-9
EINECS	Contact for details

Quality Control

Every batch of our (2R)-2,3-Bis[Bis(Trimethylsilyloxy)Phosphinyloxy]Propionic Acid Trimethylsilyl Ester is produced and tested under strict quality management protocols to ensure high chiral purity and chemical consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as enantiomeric excess, chemical purity, and identity confirmation. Our quality systems support development from research to commercial scale, ensuring reliable supply for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.