Description

Phosphoric Acid [2,2-Dimethoxy-3-[(Trimethylsilyl)Oxy]Propyl]Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphate derivative, serving as a crucial synthetic intermediate and protecting group reagent in advanced organic synthesis. Its primary value lies in its ability to introduce phosphate functionalities under controlled conditions while protecting sensitive hydroxyl groups, enabling the synthesis of complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, particularly for nucleotide chemistry, prodrug development, and the synthesis of phospholipid analogs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleotide analogs, antiviral prodrugs, and other bioactive phosphate esters.
• Protecting Group Reagent: Used to temporarily protect phosphate and hydroxyl groups during multi-step synthetic sequences, allowing for selective reactions elsewhere on the molecule.
• Agrochemical Synthesis: Intermediate in the production of specialized herbicides, insecticides, and plant growth regulators containing phosphonate or phosphate moieties.
• Material Science Research: Precursor for modifying surfaces or creating novel polymers and dendrimers with specific functional properties.
• Chemical Biology Probes: Used in the development of labeled compounds and probes for studying enzymatic processes involving phosphorylation.
• Process Chemistry: Employed in scalable routes for the GMP-compliant manufacture of active pharmaceutical ingredients (APIs) requiring phosphate functionalization.

Basic Information

Product Name	Phosphoric Acid [2,2-Dimethoxy-3-[(Trimethylsilyl)Oxy]Propyl]Bis(Trimethylsilyl) Ester
CAS No.	55319-96-5
Molecular Formula	C14H37O7PSi3
Molecular Weight	424.67 g/mol
Synonyms	Bis(trimethylsilyl) [2,2-dimethoxy-3-(trimethylsilyloxy)propyl] phosphate; Phosphoric acid, [2,2-dimethoxy-3-[(trimethylsilyl)oxy]propyl] bis(trimethylsilyl) ester; 2,2-Dimethoxy-3-(trimethylsilyloxy)propyl bis(trimethylsilyl) phosphate; TMS-protected glycerol phosphate derivative; Silyl-protected phosphoglycerol reagent
EINECS	Contact for details

Quality Control

Our production of Phosphoric Acid [2,2-Dimethoxy-3-[(Trimethylsilyl)Oxy]Propyl]Bis(Trimethylsilyl) Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and purity suitable for research and process-scale applications. Each lot is characterized by comprehensive analytical techniques including NMR, HPLC, and GC to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from incompatible materials such as strong acids/organic solvents, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.