Description

2H-1,4-Benzodiazepin-2-One, 7-Chloro-1,3-Dihydro-5-Phenyl-1-(Trimethyl Silyl)-3-[(Trimethylsilyl)Oxy]- is a key silylated intermediate in advanced organic synthesis, offering enhanced stability and reactivity for complex molecular construction. Its primary value lies in providing a protected and activated pathway for the synthesis of pharmacologically active benzodiazepine derivatives and other fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for drug discovery and process optimization.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs) and analogs.
• Process Chemistry: Used in route scouting and scale-up for the production of complex heterocyclic compounds, leveraging the silyl protecting groups.
• Research & Development: Serves as a versatile precursor in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Agrochemical Synthesis: Intermediate in the development of new crop protection agents with benzodiazepine-related scaffolds.
• Custom Synthesis: Starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals for clients.

Basic Information

Product Name	2H-1,4-Benzodiazepin-2-One, 7-Chloro-1,3-Dihydro-5-Phenyl-1-(Trimethyl Silyl)-3-[(Trimethylsilyl)Oxy]-
CAS No.	55319-93-2
Molecular Formula	C21H29ClN2O2Si2
Molecular Weight	441.10 g/mol
Synonyms	7-Chloro-1,3-dihydro-5-phenyl-1-(trimethylsilyl)-3-[(trimethylsilyl)oxy]-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-phenyl-1-(trimethylsilyl)-3-[(trimethylsilyl)oxy]-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-7-chloro-5-phenyl-1-(trimethylsilyl)-3-[(trimethylsilyl)oxy]-2H-1,4-benzodiazepin-2-one; TMS-protected 7-Chloro-5-phenyl-1,4-benzodiazepin-2-one derivative; Silylated Benzodiazepine Intermediate; CAS 55319-93-2
EINECS	Contact for details

Quality Control

Every batch of our 2H-1,4-Benzodiazepin-2-One, 7-Chloro-1,3-Dihydro-5-Phenyl-1-(Trimethyl Silyl)-3-[(Trimethylsilyl)Oxy]- is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.