Description

2β-Trimethylsilyloxy-5α-Cholestane is a high-purity, steroidal organosilicon derivative, primarily utilized as a key synthetic intermediate and analytical reference standard. Its value lies in providing a protected hydroxyl group on the cholestane backbone, enabling precise chemical modifications in complex organic syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors, particularly those developing novel steroid-based therapeutics, liquid crystals, or specialized chemical probes.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel steroid hormones, vitamin D analogs, and other bioactive steroidal compounds.
• Analytical Reference Standard: Used in HPLC, GC-MS, and NMR for method development, calibration, and quality control of steroidal products and related impurities.
• Chemical Research & Development: Serves as a protected precursor in academic and industrial R&D for exploring new chemical reactions and pathways involving steroidal frameworks.
• Material Science: Potential intermediate for synthesizing steroidal liquid crystals or other functional organic materials with specific mesomorphic properties.
• Process Chemistry: Employed in scaling up the production of specialty steroids where the trimethylsilyloxy group is a necessary protecting group.

Basic Information

Product Name	2β-Trimethylsilyloxy-5α-Cholestane
CAS No.	55282-51-4
Molecular Formula	C₃₀H₅₄OSi
Molecular Weight	450.85 g/mol
Synonyms	5α-Cholestan-2β-ol, trimethylsilyl ether; 2β-(Trimethylsiloxy)-5α-cholestane; Cholestane, 2β-(trimethylsilyloxy)-5α-; 5α-Cholestan-2β-yloxytrimethylsilane; 2β-Trimethylsiloxy-5α-cholestane; (2β,5α)-2-(Trimethylsilyloxy)cholestane
EINECS	Contact for details

Quality Control

Our 2β-Trimethylsilyloxy-5α-Cholestane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.