Description

2-Ethyl-2-Phenyl-N,N'-Bis(Trimethylsilyl)Malonamide is a specialized organosilicon-protected malonamide derivative, serving as a critical building block and protecting group reagent in advanced organic synthesis. Its value lies in its dual functionality, offering both a reactive malonamide core and robust trimethylsilyl (TMS) protecting groups that are stable under a wide range of reaction conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for constructing complex molecules, particularly in peptide mimetics and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing malonamide or β-dicarbonyl motifs.
• Peptidomimetic Synthesis: Used as a protected synthon for introducing constrained dipeptide analogs and backbone modifications in drug discovery.
• Agrochemical Development: Serves as a building block for novel herbicides, fungicides, and plant growth regulators that utilize its specific steric and electronic properties.
• Ligand and Catalyst Preparation: Employed in the preparation of chelating ligands for transition metal catalysis and organometallic chemistry.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and silicon-containing hybrid materials.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis, particularly in studies involving silyl protection/deprotection strategies.

Basic Information

Product Name	2-Ethyl-2-Phenyl-N,N'-Bis(Trimethylsilyl)Malonamide
CAS No.	55268-56-9
Molecular Formula	C19H34N2O2Si2
Molecular Weight	378.66 g/mol
Synonyms	N,N'-Bis(trimethylsilyl)-2-ethyl-2-phenylmalonamide; 2-Ethyl-2-phenylmalonamide bis(trimethylsilyl) derivative; Malonamide, 2-ethyl-2-phenyl-N,N-bis(trimethylsilyl)-; TMS-protected 2-ethyl-2-phenylmalonamide; Bis(trimethylsilyl) 2-ethyl-2-phenylmalondiamide; 2-Phenyl-2-ethylmalonamide bis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 2-Ethyl-2-Phenyl-N,N'-Bis(Trimethylsilyl)Malonamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.