Description

Silane, Trimethyl[1-Methyl-2-Oxo-2-(Trimethylsilyl)Ethoxy]-, (R)- is a specialized chiral organosilicon compound, a key building block in advanced organic synthesis. Its value lies in its ability to act as a protected chiral synthon, enabling the stereoselective construction of complex molecules with high enantiomeric purity. This compound is essential for researchers and process chemists in the pharmaceutical and fine chemical industries developing novel active ingredients and high-value intermediates.

Application

• Asymmetric Synthesis: A crucial chiral auxiliary or reagent for the stereocontrolled formation of carbon-carbon and carbon-heteroatom bonds.
• Pharmaceutical Intermediate: Used in the research and development of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.
• Natural Product Synthesis: Facilitates the total synthesis of complex natural products where specific stereocenters are required.
• Advanced Material Precursor: Serves as a starting material for synthesizing chiral ligands for catalysis or functionalized silicon-based materials.
• Process Chemistry Development: Employed in scaling up synthetic routes that require high enantioselectivity and yield for commercial production.

Basic Information

Product Name	Silane, Trimethyl[1-Methyl-2-Oxo-2-(Trimethylsilyl)Ethoxy]-, (R)-
CAS No.	55255-93-1
Molecular Formula	C11H26O2Si2
Molecular Weight	246.50 g/mol
Synonyms	(R)-Trimethyl[1-methyl-2-oxo-2-(trimethylsilyl)ethoxy]silane; (R)-1-(Trimethylsilyl)-2-(trimethylsilyloxy)propanoate; (R)-TMS-Ketene Acetal; (R)-1-Methoxy-2-methyl-1-(trimethylsilyloxy)-1-(trimethylsilyl)ethene; (R)-Methyl (Trimethylsilyl)ketene O-Trimethylsilyl Acetal; Chiral TMS Enol Ether; (R)-1-(Trimethylsilyl)-1-(trimethylsilyloxy)propene
EINECS	Contact for details

Quality Control

Our production of this high-value chiral synthon adheres to strict quality protocols to ensure batch-to-batch consistency and enantiomeric purity critical for research and development. Each lot is characterized by NMR, HPLC, and chiral GC/HPLC analysis to confirm identity, chemical purity, and enantiomeric excess (ee). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to maintain stability and prevent hydrolysis or racemization. Keep away from moisture and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 98.0% ee
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.