Description

α-Oxo-1-Trimethylsilyl-1H-Indole-3-Acetic Acid Trimethylsilyl Ester is a high-purity, protected indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. This compound is valued for its dual silyl protection, which enhances stability and provides selective reactivity for constructing complex heterocyclic frameworks. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based drug candidates, including potential kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in developing new active ingredients for crop protection products, leveraging the indole scaffold's bioactivity.
• Organic Synthesis Reagent: Employed in complex multi-step syntheses, particularly in palladium-catalyzed cross-coupling reactions and nucleophilic substitutions where protected functionalities are required.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and organic electronic materials with specific optoelectronic properties.
• Academic & Contract Research: Essential for methodological development and discovery chemistry in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	α-Oxo-1-Trimethylsilyl-1H-Indole-3-Acetic Acid Trimethylsilyl Ester
CAS No.	55191-46-3
Molecular Formula	C16H23NO3Si2
Molecular Weight	333.53 g/mol
Synonyms	1-(Trimethylsilyl)-3-[(trimethylsilyl)oxy]methylidene-1H-indol-2-one; 2-Oxo-1-(trimethylsilyl)-3-[(trimethylsilyl)oxy]methyleneindoline; 1-Trimethylsilyl-3-(trimethylsilyloxymethylene)oxindole; (1-Trimethylsilyl-2-oxoindolin-3-ylidene)methyl Trimethylsilyl Ether; 3-[(Trimethylsilyl)oxy]methylene-1-(trimethylsilyl)indolin-2-one; TMS-protected 3-Methyleneoxindole Derivative; Silyl Ether of 3-Hydroxymethylene-1-trimethylsilyloxindole
EINECS	Contact for details

Quality Control

Our α-Oxo-1-Trimethylsilyl-1H-Indole-3-Acetic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and meet the stringent requirements of research and process chemistry. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.