Description

β-(S-Benzyl)Mercapto-Beta,β-Cyclopentamethylene Propionic Acid is a specialized chiral intermediate featuring a cyclopentamethylene backbone and a benzyl-protected thiol group. This compound is valued for its role in the synthesis of complex molecules, particularly in pharmaceutical research and development where precise stereochemistry is critical. It is primarily sought by fine chemical manufacturers and R&D laboratories engaged in creating novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly those targeting cardiovascular and central nervous system disorders.
• Peptidomimetic Research: Used to introduce constrained, non-natural amino acid motifs into peptide analogs to enhance metabolic stability and binding affinity.
• Ligand Synthesis for Catalysis: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Protease Inhibitor Development: Incorporated into the structure of potential inhibitors for various enzymes like ACE or renin.
• Chemical Biology Probes: Utilized in the development of activity-based probes for studying enzyme function and mechanism.
• Academic & Industrial R&D: Employed in exploratory chemistry for methodological development and the creation of new chemical entities with potential biological activity.

Basic Information

Product Name	β-(S-Benzyl)Mercapto-Beta,β-Cyclopentamethylene Propionic Acid
CAS No.	55154-80-8
Molecular Formula	C16H20O2S
Molecular Weight	276.40 g/mol
Synonyms	3-[(Benzylthio)methyl]-2,2-dimethylcyclopentanecarboxylic Acid; (1S,3R)-3-[(Benzylsulfanyl)methyl]-2,2-dimethylcyclopentane-1-carboxylic Acid; (S)-3-(Benzylthiomethyl)-2,2-dimethylcyclopentanecarboxylic Acid; NSC 334365; β-(S-Benzyl)mercapto-β,β-cyclopentamethylenepropionic Acid; 2,2-Dimethyl-3-[(phenylmethyl)thio]methyl-1-cyclopentanecarboxylic Acid; (1S,3R)-3-[[(Phenylmethyl)thio]methyl]-2,2-dimethylcyclopentanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our β-(S-Benzyl)Mercapto-Beta,β-Cyclopentamethylene Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.