Description

1-(Trimethylsilyl)-1H-Indole-2-Acetic Acid Trimethylsilyl Ester is a versatile, silyl-protected derivative of indole-2-acetic acid, a key structural motif in bioactive chemistry. This compound is specifically engineered to enhance stability and reactivity in sensitive synthetic transformations, offering a crucial building block for advanced research and development. It is primarily utilized by pharmaceutical and agrochemical R&D teams, as well as academic researchers, for the synthesis of novel heterocyclic compounds and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key protected synthon in the multi-step synthesis of potential drug candidates, particularly those targeting neurological or anti-inflammatory pathways.
• Agrochemical Research: Used in the development of novel plant growth regulators or herbicides based on modified indole acetic acid structures.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) and other metal-mediated transformations where the silyl groups provide steric protection and influence regioselectivity.
• Material Science Precursor: Acts as a starting material for creating specialized organic ligands or functionalized monomers for advanced polymers.
• Academic & Process Chemistry: A valuable reagent for methodological development and studying the reactivity of protected heterocyclic carboxylic acid derivatives.

Basic Information

Product Name	1-(Trimethylsilyl)-1H-Indole-2-Acetic Acid Trimethylsilyl Ester
CAS No.	55125-13-8
Molecular Formula	C16H25NO2Si2
Molecular Weight	319.55 g/mol
Synonyms	1-(Trimethylsilyl)-1H-indole-2-acetic acid trimethylsilyl ester; 2-[(Trimethylsilyl)oxycarbonylmethyl]-1-(trimethylsilyl)indole; Indole-2-acetic acid, 1-(trimethylsilyl)-, trimethylsilyl ester; 1-TMS-indole-2-acetic acid TMS ester; (1-Trimethylsilyl-1H-indol-2-yl)-acetic acid trimethylsilyl ester; TMS-IAA-TMS; 55125-13-8; 1-(Trimethylsilyl)indole-2-acetic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-1H-Indole-2-Acetic Acid Trimethylsilyl Ester undergoes rigorous quality testing to ensure compliance with industry standards for research and development chemicals. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.