Description

[2-[(2,2-Dimethylpropylidene)Amino]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonate reagent, a key intermediate in advanced organic synthesis. Its primary value lies in its role as a protected phosphonic acid building block, enabling the controlled introduction of phosphonate groups under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and materials science, particularly for creating novel bioactive molecules and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly bisphosphonate analogs and prodrugs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, plant growth regulators, and pesticides containing phosphonate moieties.
• Ligand and Catalyst Preparation: Serves as a precursor for phosphonate-based ligands used in asymmetric catalysis and metal complexation.
• Peptide Mimetics and Bioconjugation: Facilitates the incorporation of stable phosphonate linkages into peptide backbones and biomolecules.
• Surface Modification and Functional Materials: Employed to create phosphonate-functionalized surfaces, polymers, and nanomaterials for specialized applications.
• Organic Synthesis Reagent: Provides a masked phosphonic acid functionality for Horner-Wadsworth-Emmons (HWE) olefination and other carbon-carbon bond-forming reactions.

Basic Information

Item	Detail
Product Name	[2-[(2,2-Dimethylpropylidene)Amino]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-78-6
Molecular Formula	C13H32NO3PSi2
Molecular Weight	337.55 g/mol
Synonyms	Bis(trimethylsilyl) [2-[(2,2-dimethylpropylidene)amino]ethyl]phosphonate; (2-((2,2-Dimethylpropylidene)amino)ethyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-[2-[(2,2-dimethylpropylidene)amino]ethyl]-, Bis(trimethylsilyl) Ester; TMS-Protected Neopentylideneaminoethylphosphonate; N-(2,2-Dimethylpropylidene)-2-aminoethylphosphonic Acid Bis(trimethylsilyl) Ester
EINECS	Contact for details

Quality Control

Our production of [2-[(2,2-Dimethylpropylidene)Amino]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by NMR (¹H, ¹³C, ³¹P), FT-IR, and GC/HPLC analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and we support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) after opening to prevent hydrolysis and maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.