Description

[(Isopropylideneamino)Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a protected phosphonic acid group and an imine functionality. This compound matters as a versatile synthetic intermediate and protecting group reagent, enabling the controlled introduction of phosphonate moieties in complex molecular architectures. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting bone diseases or requiring phosphonate bioisosteres.
• Agrochemical Synthesis: Used in the research and development of herbicides, plant growth regulators, and other crop protection agents with phosphonate backbones.
• Ligand & Catalyst Precursor: Serves as a precursor for the preparation of specialized phosphonate-based ligands used in asymmetric catalysis and metal complexation.
• Peptide & Nucleotide Chemistry: Employed in the modification of peptides and nucleotides, where the protected phosphonic acid group is used to mimic phosphate esters.
• Surface Modification Agent: Applied in materials science for the functionalization of surfaces (e.g., silica, metals) to impart specific chemical properties.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for methodology development and exploring new reaction pathways involving phosphorus chemistry.

Basic Information

Product Name	[(Isopropylideneamino)Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-63-9
Molecular Formula	C10H26NO3PSi2
Molecular Weight	295.46 g/mol
Synonyms	Phosphonic acid, P-[(1-methylethylidene)amino]methyl]-, bis(trimethylsilyl) ester; (Isopropylideneaminomethyl)phosphonic Acid Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) [(isopropylideneamino)methyl]phosphonate; (Dimethylmethyleneamino)methylphosphonic Acid Bis(trimethylsilyl) Ester; N-(Dimethylmethylene)-P,P-bis(trimethylsilyl) aminomethylphosphonamide; TMS-protected (Isopropylideneamino)methylphosphonate
EINECS	Contact for details

Quality Control

Our [(Isopropylideneamino)Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester undergoes rigorous quality testing to ensure batch-to-batch consistency and compliance with high-purity standards for research and development. We employ advanced analytical techniques including NMR, HPLC, and GC to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC or HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.