Description

1-Iodo-4-Methylbicyclo[2.2.2]octane is a highly functionalized, sterically hindered bicyclic organic compound featuring an iodine substituent, making it a valuable and versatile building block in advanced organic synthesis. Its unique rigid scaffold and reactive carbon-iodine bond are critical for constructing complex molecular architectures with precise stereochemical control. This specialty intermediate is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions, ligand synthesis, and the development of novel chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for creating sterically defined, three-dimensional structures in drug discovery programs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where the bicyclic framework can impart unique biological activity and environmental stability.
• Cross-Coupling Reactions: Acts as an efficient electrophilic coupling partner in palladium-catalyzed reactions (e.g., Suzuki, Negishi, Stille couplings) due to its reactive C-I bond.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel chiral or sterically demanding ligands for asymmetric catalysis and transition metal complexes.
• Advanced Material Synthesis: A building block for creating monomers or functional units in polymers, liquid crystals, or organic electronic materials requiring rigid, non-planar components.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, exploring new reaction pathways and mechanistic investigations.

Basic Information

Product Name	1-Iodo-4-Methylbicyclo[2.2.2]octane
CAS No.	55044-63-8
Molecular Formula	C9H15I
Molecular Weight	250.12 g/mol
Synonyms	4-Methyl-1-iodobicyclo[2.2.2]octane; 1-Iodo-4-methylbicyclo[2.2.2]octane; Bicyclo[2.2.2]octane, 1-iodo-4-methyl-; 4-Methylbicyclo[2.2.2]oct-1-yl iodide
EINECS	Contact for details

Quality Control

Our production of 1-Iodo-4-Methylbicyclo[2.2.2]octane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.