Description

(14α)-6,7-Didehydro-3-Methoxy-17-Methylmorphinan CAS NO 55028-44-9 is a high-purity, semi-synthetic morphinan derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of specialized active pharmaceutical ingredients (APIs) and reference standards. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents within the central nervous system (CNS) and analgesic domains.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex opioid and non-opioid analgesic compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in pharmacological studies to investigate receptor binding affinity, metabolic pathways, and structure-activity relationships (SAR).
• Process Development: Serves as a starting material or intermediate for scaling up API manufacturing processes under Good Manufacturing Practice (GMP) conditions.
• Metabolite Synthesis: Utilized for the preparation of specific drug metabolites required for toxicological and pharmacokinetic studies.

Basic Information

Product Name	(14α)-6,7-Didehydro-3-Methoxy-17-Methylmorphinan
CAS No.	55028-44-9
Molecular Formula	C₁₉H₂₅NO₂
Molecular Weight	299.41 g/mol
Synonyms	3-O-Methylthebaine; 3-Methoxy-6,7-didehydro-4,5α-epoxy-17-methylmorphinan; Thebaine 3-methyl ether; 3-Methoxythebaine; 6,7-Didehydro-3-methoxy-17-methyl-4,5α-epoxymorphinan; 17-Methyl-3-methoxy-6,7-didehydro-4,5α-epoxymorphinan
EINECS	Contact for details

Quality Control

Our (14α)-6,7-Didehydro-3-Methoxy-17-Methylmorphinan is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and impurity profiling, spectroscopic identification (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.