Description

Diethyl Methyl-D3-Malonate is a high-purity, isotopically labeled derivative of diethyl methylmalonate, where three hydrogen atoms on the methyl group are replaced by deuterium (D). This compound is a crucial building block in synthetic organic chemistry, particularly for the preparation of deuterated pharmaceuticals and advanced materials, where it provides excellent isotopic purity and stability. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and analytical chemistry industries for applications requiring precise isotopic labeling, such as in metabolic studies, internal standards for mass spectrometry, and the development of novel active ingredients.

Application

• Deuterated Pharmaceutical Synthesis: A key precursor for introducing a stable CD3 group into target molecules, enhancing metabolic stability and enabling pharmacokinetic studies.
• Mass Spectrometry Internal Standards: Used to create isotopically labeled internal standards for accurate quantitative analysis (LC-MS/MS, GC-MS) in bioanalytical and environmental testing.
• Agrochemical Research: Employed in the development of deuterated active ingredients to study degradation pathways and improve environmental profiles.
• Metabolic Pathway Tracing: Facilitates the study of drug metabolism and biochemical pathways in vivo using deuterium as a non-radioactive tracer.
• NMR Spectroscopy: Serves as a useful reagent or intermediate in the synthesis of compounds for nuclear magnetic resonance (NMR) studies.
• Material Science: A building block for specialized polymers or organic electronic materials where deuterium substitution can alter physical properties.

Basic Information

Product Name	Diethyl Methyl-D3-Malonate
CAS No.	54840-57-2
Molecular Formula	C8H11D3O4
Molecular Weight	177.20 g/mol
Synonyms	Diethyl (Methyl-d3)malonate; Diethyl 2-(Methyl-d3)malonate; Propanedioic acid, 2-(methyl-d3)-, diethyl ester; Methyl-d3-malonic Acid Diethyl Ester; Diethyl (Trideuteriomethyl)propanedioate; Diethyl 2-(Trideuteriomethyl)malonate; Malonic acid, methyl-d3-, diethyl ester; Diethyl Methyl(methyl-d3)malonate
EINECS	Contact for details

Quality Control

Our Diethyl Methyl-D3-Malonate is manufactured under strict quality systems to ensure high isotopic and chemical purity, meeting the exacting requirements of research and development. Each batch is characterized by advanced analytical techniques including NMR, GC-MS, and HPLC to confirm identity, isotopic enrichment (typically ≥98 atom % D), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.