Description

α-(Trimethylsilyl)Oxy-1H-Indole-1-Propanoic Acid Methyl Ester is a specialized organosilicon-protected indole derivative that serves as a critical synthetic intermediate. Its value lies in providing a protected, reactive handle for the controlled functionalization of the indole nucleus, enabling complex molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of indole-based drug candidates, including potential serotonin receptor modulators and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that leverage the indole scaffold for biological activity.
• Organic Synthesis Reagent: Serves as a versatile precursor for introducing functionalized indole units into more complex molecular architectures via cross-coupling or further derivatization.
• Material Science Research: Potential monomer or intermediate for creating specialized polymers and advanced organic materials with unique electronic properties.
• Academic & R&D Laboratories: A valuable tool for methodological development in synthetic organic chemistry, particularly in studies involving silyl protecting group strategies.

Basic Information

Product Name	α-(Trimethylsilyl)Oxy-1H-Indole-1-Propanoic Acid Methyl Ester
CAS No.	54833-73-7
Molecular Formula	C15H21NO3Si
Molecular Weight	291.42 g/mol
Synonyms	1H-Indole-1-propanoic acid, α-[(trimethylsilyl)oxy]-, methyl ester; Methyl 3-(1H-indol-1-yl)-2-[(trimethylsilyl)oxy]propanoate; Methyl α-(trimethylsilyloxy)-1H-indole-1-propionate; 1-(2-Methoxy-1-[(trimethylsilyl)oxy]-2-oxoethyl)-1H-indole; TMS-protected indole propionate methyl ester
EINECS	Contact for details

Quality Control

Our production of α-(Trimethylsilyl)Oxy-1H-Indole-1-Propanoic Acid Methyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.