Description

1-Iodo-2-Propyn-1-Ol is a versatile halogenated propargylic alcohol building block with significant synthetic utility. Its unique structure, featuring both an iodine atom and a terminal alkyne, makes it a valuable precursor for cross-coupling reactions and the construction of complex molecular frameworks. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce functionalized propargyl units into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing iodinated or alkyne-functionalized structures.
• Agrochemical Synthesis: Used in the production of novel fungicides, herbicides, and plant growth regulators that leverage its reactive halogen and alkyne groups.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Organic Synthesis Building Block: Employed in Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Chemical Research & Development: A crucial reagent for medicinal chemistry and process chemistry in the discovery and optimization of new chemical entities.
• Ligand and Catalyst Preparation: Used to synthesize specialized ligands for metal catalysis or to functionalize surfaces and nanoparticles.

Basic Information

Product Name	1-Iodo-2-Propyn-1-Ol
CAS No.	54724-99-1
Molecular Formula	C3H3IO
Molecular Weight	197.96 g/mol
Synonyms	3-Iodo-2-propyn-1-ol; 3-Iodoprop-2-yn-1-ol; Iodopropargyl Alcohol; Propargyl Iodide, Hydroxy-; 1-Iodo-2-propynol; 2-Propyn-1-ol, 1-iodo-; HC≡CCH2I(OH) (common representation)
EINECS	Contact for details

Quality Control

Our 1-Iodo-2-Propyn-1-Ol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of industrial and research applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Keep away from heat, sparks, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.