Description

[S,(+)]-1-Chloro-2,3-Dimethylbutane CAS NO 54665-36-0 is a high-purity, chiral organochlorine compound characterized by its specific stereochemistry at the chiral center. This compound serves as a valuable chiral building block and intermediate in advanced organic synthesis, enabling the production of enantiomerically pure pharmaceuticals and agrochemicals. It is primarily utilized by research institutions and industrial R&D departments focused on asymmetric synthesis, medicinal chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug research.
• Agrochemical Synthesis: Used in the development of chiral pesticides and herbicides, where the specific stereochemistry can be critical for biological activity and environmental safety.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development and testing of new chiral catalysts and methodologies.
• Flavor & Fragrance Industry: Serves as an intermediate for the synthesis of specific, high-value chiral aroma chemicals.
• Material Science: Potential monomer or modifying agent for creating specialized polymers with unique optical or physical properties.
• Academic & Industrial R&D: A standard reagent for methodological studies in stereoselective alkylation and functional group transformation reactions.

Basic Information

Product Name	[S,(+)]-1-Chloro-2,3-Dimethylbutane
CAS No.	54665-36-0
Molecular Formula	C6H13Cl
Molecular Weight	120.62 g/mol
Synonyms	(S)-(+)-1-Chloro-2,3-dimethylbutane; (S)-1-Chloro-2,3-dimethylbutane; (+)-1-Chloro-2,3-dimethylbutane; (2S)-1-Chloro-2,3-dimethylbutane; 1-Chloro-2,3-dimethylbutane, (S)-; 2,3-Dimethylbutyl chloride, (S)-(+)-; Butane, 1-chloro-2,3-dimethyl-, (S)-
EINECS	Contact for details

Quality Control

Our [S,(+)]-1-Chloro-2,3-Dimethylbutane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by GC or HPLC, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C/59-77°F). Due to its highly volatile nature, keep containers tightly sealed when not in use and away from heat, sparks, and open flame. Keep away from strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Specific Rotation [α]20/D	Contact for details
Refractive Index n20/D	Contact for details
Density	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.