Description

3-Aminopropyl Silica Gel (0.6-1.3Mmol/G) is a high-purity, functionalized chromatographic support material widely used as a stationary phase in separation science. Its primary value lies in its well-defined amino-propyl ligand density, which provides consistent and reproducible performance for the separation of polar compounds, carbohydrates, and organic acids. This product is essential for industries requiring high-resolution purification and analysis, including pharmaceutical development, biotechnology, and analytical chemistry laboratories. The controlled functional group loading ensures optimal selectivity and capacity for a range of normal-phase and hydrophilic interaction liquid chromatography (HILIC) applications.

Application

• Normal-Phase Chromatography: As a stationary phase for the separation of polar analytes, including pharmaceuticals, natural products, and synthetic intermediates.
• Hydrophilic Interaction Liquid Chromatography (HILIC): For the retention and analysis of highly polar and hydrophilic compounds that are poorly retained in reversed-phase LC.
• Solid-Phase Extraction (SPE): Used in sample preparation cartridges for the selective extraction and clean-up of acidic compounds, anions, and carbohydrates from complex matrices.
• Affinity Chromatography: Serves as a support for the immobilization of ligands, enzymes, or antibodies in bioprocessing and purification workflows.
• Catalyst Support: As a heterogeneous catalyst support in organic synthesis, where the aminopropyl groups can be further modified or used directly for catalytic reactions.
• Analytical Method Development: A key material for developing and validating analytical methods in quality control (QC) and research & development (R&D) laboratories.

Basic Information

Product Name	3-Aminopropyl Silica Gel (0.6-1.3Mmol/G)
CAS No.	54088-50-5
Molecular Formula	Contact for details
Molecular Weight	N/A (Functionalized Silica)
Synonyms	Aminopropyl silica; 3-Aminopropyl-functionalized silica gel; Aminopropyl-modified silica; Propylamine silica gel; NH2-silica; Silica gel, 3-aminopropylsilylated; Aminopropyl bonded silica; APS silica; LC-NH2 phase; HILIC-NH2 stationary phase
EINECS	Contact for details

Quality Control

Our 3-Aminopropyl Silica Gel is manufactured under strict quality management protocols. Each batch is characterized for critical parameters including ligand density, particle size distribution, surface area, and pore volume to ensure chromatographic performance and batch-to-batch consistency. Certificates of Analysis (COA) documenting these specifications are provided with every shipment. Our quality system is designed to support applications requiring reliable and reproducible separation media.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed when not in use to prevent moisture uptake, which can affect performance. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white free-flowing powder
Aminopropyl Ligand Density	0.6 - 1.3 mmol/g
Particle Size	3, 5, or 10 µm (other sizes available)
Pore Size	Typically 100 Å (Contact for details)
Surface Area	Contact for details
Carbon Load (%C)	Determined by batch (COA)
pH (in water slurry)	Contact for details
Loss on Drying	< 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.