Description

Dl-Alanine-2,3,3,3-D4 is a stable isotope-labeled analog of the amino acid alanine, specifically deuterated at the 2, 3, 3, and 3 positions. This compound is essential as an internal standard in quantitative mass spectrometry, enabling precise measurement and analysis of alanine in complex biological and chemical matrices. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, metabolic research, and analytical chemistry for applications requiring high isotopic purity and traceability.

Application

• Mass Spectrometry Internal Standard: Serves as a critical reference compound for the accurate quantification of endogenous alanine in bioanalytical studies using LC-MS and GC-MS.
• Metabolic Pathway Tracing: Used in stable isotope labeling experiments (SIL) to investigate amino acid metabolism, protein turnover, and metabolic flux analysis.
• Pharmaceutical Research: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug compounds and their interactions with amino acids.
• NMR Spectroscopy: Acts as a deuterated solvent or a probe in nuclear magnetic resonance studies due to its specific isotopic labeling.
• Biochemical Reagent: Used in the synthesis of labeled peptides, proteins, and other biomolecules for research and diagnostic purposes.
• Quality Control in Manufacturing: Applied as a standard in the quality assurance processes for amino acid-based products and nutritional supplements.

Basic Information

Product Name	Dl-Alanine-2,3,3,3-D4
CAS No.	53795-92-9
Molecular Formula	C₃H₃D₄NO₂
Molecular Weight	92.12 g/mol
Synonyms	(±)-2-Amino-2,3,3,3-tetradeuteriopropanoic acid; DL-Alanine-d4; DL-2-Aminopropionic acid-d4; Alanine-2,3,3,3-d4; (RS)-Alanine-d4; 2-Aminopropanoic acid-2,3,3,3-d4; NSC 7605-d4; DL-α-Alanine-d4
EINECS	Contact for details

Quality Control

Our Dl-Alanine-2,3,3,3-D4 is produced under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), and chiral purity. We support research and industrial standards, and specifications can be aligned with customer requirements for specific applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.