Description

3-Amino-Tetrahydro-Thiophene-3-Carboxylic Acid Hydrochloride is a high-purity, non-proteinogenic amino acid derivative featuring a tetrahydrothiophene (thiophane) ring, which is of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and a constrained scaffold for designing novel bioactive molecules, particularly in medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of peptide mimetics, enzyme inhibitors, and other therapeutic agents targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Medicinal Chemistry Research: Serves as a versatile scaffold in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.
• Enzyme Inhibitor Development: Potential building block for designing inhibitors of proteases and other enzymes due to its unique sulfur-containing heterocyclic structure.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological pathways and protein function.
• Academic & Industrial R&D: Fundamental research in organic synthesis and the development of new synthetic methodologies involving sulfur heterocycles.

Basic Information

Product Name	3-Amino-Tetrahydro-Thiophene-3-Carboxylic Acid Hydrochloride
CAS No.	53747-09-4
Molecular Formula	C5H10ClNO2S
Molecular Weight	183.66 g/mol
Synonyms	3-Amino-3-carboxytetrahydrothiophene hydrochloride; 3-Aminothiophane-3-carboxylic acid hydrochloride; (3-Aminooxolan-3-yl)methanethiol hydrochloride (incorrect but common misnomer); 3-Amino-tetrahydro-thiophene-3-carboxylic acid HCl; ATCA hydrochloride; 3-Amino-3-(carboxy)thiophane hydrochloride; 3-Amino-3-thiophane carboxylic acid hydrochloride; Tetrahydro-3-amino-3-thiophenecarboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Amino-Tetrahydro-Thiophene-3-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided for every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.