Description

(S)-(+)-1,2,3,4-Tetrahydro-1-Naphthol is a high-purity, single-enantiomer chiral building block of significant importance in asymmetric synthesis. This optically active alcohol is a versatile intermediate for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and advanced materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce chiral tetralin motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drug candidates, particularly those containing tetralin or related fused-ring systems.
• Asymmetric Catalyst Ligand Precursor: Used in the development and preparation of chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Agrochemical Synthesis: Serves as a building block for creating chiral active ingredients in herbicides, fungicides, and insecticides where specific stereochemistry impacts biological activity.
• Material Science Research: Employed in the synthesis of chiral liquid crystals, polymers, or other advanced organic materials with specific optical properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, exploring new asymmetric reactions and synthetic pathways.

Basic Information

Product Name	(S)-(+)-1,2,3,4-Tetrahydro-1-Naphthol
CAS No.	53732-47-1
Molecular Formula	C10H12O
Molecular Weight	148.20 g/mol
Synonyms	(S)-(+)-1,2,3,4-Tetrahydro-1-naphthalenol; (1S)-1,2,3,4-Tetrahydro-1-naphthol; (S)-1,2,3,4-Tetrahydro-1-naphthol; (S)-1,2,3,4-Tetrahydro-1-hydroxynaphthalene; (S)-1,2,3,4-Tetrahydro-1-naphthalenol; (S)-α-Tetralol; (S)-Tetrahydro-1-naphthol; (S)-Tetralol
EINECS	Contact for details

Quality Control

Our production of (S)-(+)-1,2,3,4-Tetrahydro-1-Naphthol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analysis, including chiral HPLC for enantiomeric excess (ee) determination, identity confirmation by IR and NMR spectroscopy, and purity assessment. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Specific Rotation [α]	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.