Description

Imidazole-4,5-D2 is a deuterated analog of the fundamental heterocyclic compound imidazole, where two hydrogen atoms at the 4 and 5 positions are replaced with the stable isotope deuterium. This isotopic labeling is critical for applications requiring precise molecular tracking and reduced metabolic interference, offering enhanced stability and distinct spectroscopic properties. It is an essential building block and tracer for researchers and manufacturers in pharmaceutical development, agrochemical research, and advanced material science, particularly in NMR spectroscopy and mass spectrometry studies.

Application

• Pharmaceutical Research & Development: Used as a deuterated internal standard in LC-MS and GC-MS for accurate quantitative bioanalysis of drug candidates and metabolites.
• Metabolic Pathway Tracing: Serves as a stable isotopic tracer in pharmacokinetic and metabolic stability studies to investigate drug absorption, distribution, metabolism, and excretion (ADME).
• NMR Spectroscopy Solvent & Reagent: Employed in nuclear magnetic resonance (NMR) spectroscopy as a chemical shift reference or to prepare deuterated solvents for complex molecular structure elucidation.
• Agrochemical Development: Utilized in the synthesis and analysis of novel deuterated pesticides and herbicides to study environmental fate and degradation pathways.
• Material Science: Acts as a precursor or modifying agent in the synthesis of specialized deuterated polymers, liquid crystals, and coordination complexes.
• Academic & Industrial Research: Fundamental reagent in mechanistic organic chemistry studies, catalysis research, and the development of new synthetic methodologies involving imidazole scaffolds.

Basic Information

Product Name	Imidazole-4,5-D2
CAS No.	53716-58-8
Molecular Formula	C3D2H2N2
Molecular Weight	70.10 g/mol
Synonyms	1,3-Diazole-4,5-D2; 1H-Imidazole-4,5-D2; 4,5-Dideutero-1H-imidazole; Deuterated Imidazole (4,5-D2); Imidazole-d2 (4,5); Glyoxaline-4,5-D2; Imidazole, 4,5-dideutero-; 4,5-Dideuteroimidazole
EINECS	Contact for details

Quality Control

Our Imidazole-4,5-D2 is produced under controlled conditions to ensure high isotopic purity and chemical integrity. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to confirm deuterium incorporation level, chemical purity, and the absence of critical impurities. We provide comprehensive Certificates of Analysis (COA) with detailed specifications upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.