Description

(1S)-1,2-Dimethyl-3,4-Dihydro-1H-Isoquinoline-6,7-Diol is a chiral, substituted isoquinoline derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters as a key synthetic intermediate or potential pharmacophore for developing novel therapeutic agents, particularly in neurological and cardiovascular research. Industries that need it include pharmaceutical R&D, fine chemical manufacturing, and academic research institutions focused on alkaloid chemistry and medicinal chemistry. Its specific stereochemistry and catechol moiety make it a valuable building block for targeted molecular design.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of potential drug candidates targeting neurological pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies in drug discovery programs.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural product analogs and specialty alkaloids.
• Biochemical Research: Potential use as a tool compound or ligand in enzymatic and receptor binding studies due to its catechol structure.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective chemical transformations.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(1S)-1,2-Dimethyl-3,4-Dihydro-1H-Isoquinoline-6,7-Diol
CAS No.	53622-85-8
Molecular Formula	C11H13NO2
Molecular Weight	191.23 g/mol
Synonyms	(S)-1,2-Dimethyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol; 6,7-Dihydroxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinoline; (1S)-1,2-Dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; NSC 113928; (S)-1,2-Dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; 1,2-Dimethyl-1,2,3,4-tetrahydro-6,7-isoquinolinediol (S-form)
EINECS	Contact for details

Quality Control

Our (1S)-1,2-Dimethyl-3,4-Dihydro-1H-Isoquinoline-6,7-Diol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including chiral purity verification, to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.