Description

Dl-4-Hydroxy-3-Methoxymandelic-2-D1 Acid is a deuterated derivative of vanillylmandelic acid (VMA), a key metabolite in catecholamine biosynthesis and breakdown pathways. This compound is of significant value as a stable isotope-labeled internal standard for precise analytical quantification in clinical and biochemical research. It is primarily required by pharmaceutical R&D laboratories, clinical diagnostic manufacturers, and academic institutions conducting advanced metabolic studies.

Application

• Internal Standard for Mass Spectrometry: Essential for the accurate quantification of endogenous VMA and related metabolites in LC-MS/MS and GC-MS assays.
• Clinical Diagnostics: Used in the development and calibration of in-vitro diagnostic (IVD) kits for detecting neuroendocrine tumors and disorders like pheochromocytoma.
• Biomedical Research: Serves as a critical tracer in metabolic pathway analysis, pharmacokinetic studies, and biomarker discovery related to the adrenergic system.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies for drugs affecting catecholamine pathways.
• Reference Standard: Provides a certified reference material for method validation and quality control in analytical laboratories.
• Isotope Dilution Analysis: Enables high-precision measurements in complex biological matrices such as urine, plasma, and tissue samples.

Basic Information

Product Name	Dl-4-Hydroxy-3-Methoxymandelic-2-D1 Acid
CAS No.	53587-34-1
Molecular Formula	C9H9DO5
Molecular Weight	199.18 g/mol (approx.)
Synonyms	DL-4-Hydroxy-3-methoxymandelic-2-d1 acid; Deuterated DL-Vanillylmandelic Acid; (RS)-4-Hydroxy-3-methoxymandelic-2-d1 acid; 3-Methoxy-4-hydroxymandelic-2-d1 acid; DL-VMA-2-d1; (±)-VMA-d1; 2-Deuterio-2-(4-hydroxy-3-methoxyphenyl)glycolic acid; 4-Hydroxy-3-methoxyphenylglycolic-2-d1 acid
EINECS	Contact for details

Quality Control

Our Dl-4-Hydroxy-3-Methoxymandelic-2-D1 Acid is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (deuterium content), and identification. We adhere to relevant standards for fine chemicals and reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.