Description

4-Hydroxy-3-Methoxyphenylacetic-2,2-D2 Acid is a deuterium-labeled derivative of homovanillic acid, a key metabolite in neurotransmitter research. This compound is specifically valued for its use as an internal standard in mass spectrometry, enhancing the accuracy and reliability of quantitative analytical methods. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers engaged in neurochemical analysis, biomarker discovery, and drug metabolism studies.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of homovanillic acid and related catecholamine metabolites in biological matrices like plasma, urine, and cerebrospinal fluid.
• Neurochemical Research: Used in studies of dopamine metabolism and neurological disorders such as Parkinson's disease.
• Biomarker Assay Development: Employed in the development and validation of clinical diagnostic tests.
• Stable Isotope Labeling: Serves as a labeled precursor or reference compound in metabolic pathway tracing and pharmacokinetic studies.
• Pharmaceutical Quality Control: Applied in the analysis of drug substances and metabolites to ensure product purity and consistency.
• Forensic Toxicology: Utilized in analytical methods for the detection of specific metabolites in forensic samples.

Basic Information

Product Name	4-Hydroxy-3-Methoxyphenylacetic-2,2-D2 Acid
CAS No.	53587-33-0
Molecular Formula	C9H8D2O4
Molecular Weight	184.19 g/mol
Synonyms	Homovanillic-2,2-d2 Acid; 4-Hydroxy-3-methoxybenzeneacetic-2,2-d2 Acid; 3-Methoxy-4-hydroxyphenylacetic-2,2-d2 Acid; HVA-d2; (4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid; 3-Methoxy-4-hydroxybenzeneacetic-2,2-d2 Acid; Deuterated Homovanillic Acid; D2-HVA
EINECS	Contact for details

Quality Control

Every batch of our 4-Hydroxy-3-Methoxyphenylacetic-2,2-D2 Acid is produced and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing batch-specific results for identity, purity, isotopic enrichment, and residual solvents, ensuring traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.