Description

(4-Hydroxy-3-Methoxyphenyl-D3)Acetic-2,2-D2 Acid CAS NO 53587-32-9 is a deuterium-labeled analog of homovanillic acid, a key metabolite in neurotransmitter pathways. This stable isotope-labeled compound is essential for creating precise internal standards in quantitative analytical methods, ensuring accurate and reliable measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and diagnostic manufacturers for advanced applications in bioanalytical chemistry and metabolomics studies.

Application

• Internal Standard for LC-MS/MS: Used as a critical reference standard in the quantitative analysis of homovanillic acid and related catecholamine metabolites in biological matrices like plasma, urine, and cerebrospinal fluid.
• Biomarker Research: Enables precise tracking and quantification in studies related to neurological disorders, such as Parkinson's disease, and neuroendocrine tumors.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a stable isotope-labeled tracer in ADME (Absorption, Distribution, Metabolism, and Excretion) studies for drug candidates.
• Clinical Diagnostics: Employed in the development and calibration of high-sensitivity diagnostic assays for neurotransmitter disorders.
• Metabolomics Profiling: Facilitates accurate quantification in large-scale metabolic profiling studies to understand disease mechanisms.
• Quality Control in Pharmaceutical Manufacturing: Acts as a reference material to ensure the accuracy and consistency of analytical methods used in quality control laboratories.

Basic Information

Product Name	(4-Hydroxy-3-Methoxyphenyl-D3)Acetic-2,2-D2 Acid
CAS No.	53587-32-9
Molecular Formula	C9H5D5O4
Molecular Weight	187.22 g/mol
Synonyms	Homovanillic Acid-d5; HVA-d5; 3-Methoxy-4-hydroxyphenylacetic Acid-d5; 4-Hydroxy-3-methoxybenzeneacetic-d5 Acid; (3-Methoxy-4-hydroxyphenyl)acetic-2,2-d2 Acid-d3; Deuterated Homovanillic Acid; D5-HVA; 3-Methoxy-4-hydroxybenzeneacetic Acid-d5
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems. Each batch of (4-Hydroxy-3-Methoxyphenyl-D3)Acetic-2,2-D2 Acid undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment, and purity specifications. Our quality commitment ensures compliance with the standards required for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.