Description

3-(3,4-Dihydroxyphenyl-2,5,6-D3)-L-Alanine is a deuterium-labeled isotopologue of L-DOPA, a critical precursor in neurotransmitter synthesis. This high-purity, stable-labeled compound is essential for advanced analytical and research applications where precise molecular tracking is required. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and academic institutions engaged in metabolic studies, pharmacokinetics, and the development of deuterated drug candidates.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference in LC-MS and GC-MS analyses for accurate measurement of endogenous L-DOPA and related metabolites.
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to elucidate the biosynthesis, distribution, and catabolism of catecholamines like dopamine and norepinephrine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) for deuterated pharmaceutical compounds.
• Deuterated Drug Candidate Synthesis: Acts as a key building block in the research and development of deuterium-labeled therapeutics aimed at improving metabolic stability and efficacy.
• Biochemical Assay Development: Employed in the creation of highly specific and sensitive diagnostic assays for neurological and endocrine disorders.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Provides a non-radioactive tracer for advanced structural and dynamic studies of biomolecular systems.

Basic Information

Product Name	3-(3,4-Dihydroxyphenyl-2,5,6-D3)-L-Alanine
CAS No.	53587-29-4
Molecular Formula	C9H8D3NO4
Molecular Weight	200.21 g/mol
Synonyms	L-DOPA-2,5,6-D3; (2S)-2-Amino-3-(2,5,6-trideuterio-3,4-dihydroxyphenyl)propanoic Acid; Deuterated L-DOPA; 3,4-Dihydroxy-D3-phenylalanine; Levodopa-D3; (-)-3-(3,4-Dihydroxyphenyl)-2,5,6-D3-alanine; 3-Hydroxy-L-tyrosine-D3
EINECS	Contact for details

Quality Control

Every batch of our 3-(3,4-Dihydroxyphenyl-2,5,6-D3)-L-Alanine is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR, HPLC, and MS. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and all relevant analytical data are provided with each shipment to ensure compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.