Description

Trimethylsilyl-D(-)Fructose is a silylated derivative of the natural sugar D-(-)-fructose, designed to enhance stability and reactivity for advanced synthetic applications. This specialized reagent is critical for protecting sensitive hydroxyl groups during complex multi-step organic synthesis, particularly in environments where standard protecting groups are unstable. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the production of novel compounds and intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Serves as a key protected building block in the synthesis of nucleoside analogs, carbohydrate-based drugs, and complex natural product derivatives.
• Agrochemical Research: Used in developing new sugar-based pesticides, herbicides, and plant growth regulators where specific stereochemistry is required.
• Glycochemistry & Glycobiology: Acts as a crucial intermediate for preparing glycosylation donors and acceptors in the study and synthesis of oligosaccharides and glycoconjugates.
• Chiral Pool Synthesis: Provides a readily available chiral template from the natural D-(-)-fructose pool for the asymmetric synthesis of non-carbohydrate targets.
• Analytical Chemistry: Employed as a derivatization agent in Gas Chromatography (GC) and Mass Spectrometry (MS) for the analysis of sugars and related compounds.
• Material Science Research: Investigated for creating novel sugar-based polymers, surfactants, or coatings with specific functional properties.

Basic Information

Product Name	Trimethylsilyl-D(-)Fructose
CAS No.	53538-03-7
Molecular Formula	C15H34O6Si4
Molecular Weight	438.78 g/mol
Synonyms	D-(-)-Fructose Trimethylsilyl Ether; Per-O-trimethylsilyl-D-(-)-fructose; D-(-)-Fructose, TMS derivative; 1,3,4,5,6-Penta-O-trimethylsilyl-D-(-)-fructopyranose; TMS-Fructose; D-Fructose per(trimethylsilyl) ether; NSC 334503
EINECS	Contact for details

Quality Control

Our Trimethylsilyl-D(-)Fructose is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent decomposition. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.