Description

n-Benzoyl-D5-Glycine is a stable isotope-labeled analog of the endogenous metabolite hippuric acid, where five hydrogen atoms are replaced by deuterium. This high-purity compound is essential for applications requiring precise internal standards in quantitative mass spectrometry, ensuring accurate and reliable analytical results. It is primarily used by researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and metabolomics fields for method development and validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of hippuric acid and related metabolites in biological matrices.
• Metabolomics Research: Used in stable isotope dilution analysis to study metabolic pathways, biomarker discovery, and disease mechanisms with high precision.
• Pharmaceutical Development: Employed in pharmacokinetic and pharmacodynamic studies to track drug metabolism and excretion profiles.
• Clinical Diagnostics: Facilitates the precise quantification of hippuric acid in urine and plasma for assessing liver and kidney function, as well as exposure to certain chemicals like toluene.
• Food & Nutrition Science: Applied in research analyzing polyphenol metabolism and gut microbiome activity where hippuric acid is a key metabolite.
• Environmental & Occupational Health: Aids in biomonitoring studies to accurately measure human exposure to aromatic solvents.

Basic Information

Product Name	n-Benzoyl-D5-Glycine
CAS No.	53518-98-2
Molecular Formula	C9H4D5NO3
Molecular Weight	190.20 g/mol
Synonyms	Hippuric Acid-d5; Benzoylglycine-d5; N-Benzoylglycine-d5; (Benzoyl-d5)aminoacetic Acid; N-(Benzoyl-d5)glycine; Bz-Gly-d5; 2-[(Pentadeuterobenzoyl)amino]acetic Acid; N-(Phenyl-d5-carbonyl)glycine
EINECS	Contact for details

Quality Control

Our n-Benzoyl-D5-Glycine is manufactured under strict quality management systems to ensure exceptional isotopic and chemical purity, critical for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and confirming identity and absence of critical impurities. We adhere to relevant industry standards for stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥98 atom % D
Chemical Purity (Titration)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.