Description

4-Methylbenzoic Acid Trimethylsilyl Ester is a versatile organosilicon derivative of p-toluic acid, serving as a key protected intermediate in advanced organic synthesis. Its primary value lies in providing a robust, silyl-protected carboxyl group that is stable under a wide range of reaction conditions, enabling precise multi-step synthetic sequences. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to construct complex molecular architectures with high fidelity.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where protection of the carboxylic acid functionality is required during peptide coupling or other sensitive reactions.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators that incorporate substituted benzoic acid motifs.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing organic semiconductors and liquid crystal compounds that require precise steric and electronic properties.
• Polymer Modification Agent: Employed to introduce functional groups into polymer chains or to create specialized monomers for high-performance resins.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating biaryl structures after deprotection or further functionalization.
• Analytical Chemistry Standard: Utilized as a reference standard or derivatization agent in gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) for the analysis of carboxylic acids.

Basic Information

Product Name	4-Methylbenzoic Acid Trimethylsilyl Ester
CAS No.	53358-36-4
Molecular Formula	C11H16O2Si
Molecular Weight	208.33 g/mol
Synonyms	p-Toluic Acid Trimethylsilyl Ester; Trimethylsilyl 4-Methylbenzoate; 4-Methylbenzoic Acid TMS Ester; TMS p-Toluate; (4-Methylphenyl)carboxylic Acid Trimethylsilyl Ester; Benzoic Acid, 4-methyl-, trimethylsilyl ester; Trimethyl(4-methylbenzoyloxy)silane
EINECS	Contact for details

Quality Control

Our 4-Methylbenzoic Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay and impurity profiles. Our quality system supports compliance with cGMP and ISO standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.