Description

[α-[(Trimethylsilyl)Amino]Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative, serving as a critical synthetic intermediate and protecting group reagent. Its primary value lies in enabling complex organic synthesis, particularly in the preparation of bioactive molecules and advanced materials where precise control over phosphorus-containing functional groups is required. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and materials science who require high-purity, moisture-sensitive building blocks for advanced chemical transformations.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those containing phosphonate or phosphonic acid moieties with potential biological activity.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and plant growth regulators that utilize phosphorus chemistry.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized phosphonate-based ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Peptide Mimetics and Prodrug Development: Employed in the design of phosphonate-containing peptide analogs and prodrugs to enhance stability, bioavailability, and targeting.
• Surface Modification and Material Science: Used to functionalize surfaces and polymers with specific phosphorus-containing groups for adhesion, corrosion resistance, or biocompatibility.
• Chemical Biology Research: A valuable tool for probing enzyme mechanisms and biological pathways involving phosphate esters and anhydrides.

Basic Information

Product Name	[α-[(Trimethylsilyl)Amino]Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	53122-00-2
Molecular Formula	C17H34NO3PSi3
Molecular Weight	415.68 g/mol
Synonyms	Bis(trimethylsilyl) [α-[(trimethylsilyl)amino]phenethyl]phosphonate; Phosphonic acid, P-[2-[(trimethylsilyl)amino]-1-phenylethyl]-, bis(trimethylsilyl) ester; α-[(Trimethylsilyl)amino]phenethylphosphonic acid bis(trimethylsilyl) ester; TMS-protected aminophenethylphosphonate; Silylated Phosphonate Ester; (2-((Trimethylsilyl)amino)-1-phenylethyl)phosphonic Acid Bis(trimethylsilyl) Ester
EINECS	Contact for details

Quality Control

Our [α-[(Trimethylsilyl)Amino]Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep the container tightly sealed when not in use and store away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.