Description

2-Acetylamino-1-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-2-Deoxy-β-D-Mannopyranose is a highly functionalized, protected carbohydrate derivative, specifically a per-silylated N-acetyl mannosamine. This compound is a critical advanced synthetic intermediate for the preparation of complex oligosaccharides, glycoconjugates, and biologically active molecules. It is primarily utilized by research institutions and pharmaceutical development teams working in glycoscience, medicinal chemistry, and the synthesis of novel therapeutics and diagnostics.

Application

• Glycochemistry Research: A key protected building block for the solid-phase and solution-phase synthesis of complex oligosaccharides and glycans.
• Medicinal Chemistry: Intermediate in the development of glycosidase inhibitors, glycomimetics, and carbohydrate-based drug candidates.
• Bioconjugation: Used to introduce mannosamine moieties into proteins, peptides, or other biomolecules for targeted drug delivery or diagnostic applications.
• Chemical Biology Probes: Synthesis of labeled (e.g., fluorescent, isotopic) sugar analogs for metabolic labeling and studying glycosylation pathways.
• Sialic Acid Precursor: Serves as a protected precursor in the synthetic routes toward sialic acid derivatives and analogs.
• Process Development: Used in scaling up synthetic routes for carbohydrate-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	2-Acetylamino-1-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-2-Deoxy-β-D-Mannopyranose
CAS No.	53110-71-7
Molecular Formula	C22H51NO6Si4
Molecular Weight	554.0 g/mol
Synonyms	1,3,4,6-Tetra-O-trimethylsilyl-2-acetamido-2-deoxy-β-D-mannopyranose; 2-Acetamido-1,3,4,6-tetra-O-trimethylsilyl-2-deoxy-β-D-mannopyranose; N-Acetyl-1,3,4,6-tetra-O-trimethylsilyl-β-D-mannosamine; Per-O-trimethylsilylated N-Acetylmannosamine; TMS-protected N-Acetyl-D-mannosamine; β-D-ManNAc(1,3,4,6-OTMS)4; 2-Deoxy-2-acetamido-1,3,4,6-tetra-O-(trimethylsilyl)-β-D-mannopyranose
EINECS	Contact for details

Quality Control

Our high-purity carbohydrate intermediates are manufactured under controlled conditions to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent decomposition. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.